RA Guidelines
2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis.
Singh JA, et al. Arthritis Rheumatol. 2016;68(1):1-26.
Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions.
Smolen JS, et al. Ann Rheum Dis. 2013;72(4):482-492.
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update.
Smolen JS, et al. Ann Rheum Dis. 2017;76(6):960-977.
Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force.
Smolen JS, et al. Ann Rheum Dis. 2016;75(1):3-15.
IBD Guidelines
ACG Clinical Guideline: Management of Crohn's Disease in Adults.
Lichtenstein GR, et al. Am J Gastroenterol. 2018;113:481-517.
Ulcerative Colitis Care Pathway.
Dassopoulos T, et al. Gastroenterology. 2015;149(1):238-245.
Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target.
Peyrin-Biroulet L, et al. Am J Gastroenterol. 2015;110(9):1324-1338.
European Crohn’s and Colitis Organisation
RA Patient and Provider Resources
American College of Rheumatology Disease Overview
The American College of Rheumatology has published a concise overview to help patients and caregivers learn more about rheumatoid arthritis and to provide tips for living well with this rheumatic disease.
American College of Rheumatology Patient Education Videos
The American College of Rheumatology has produced a library of videos about the impact of rheumatic disease, what to do when diagnosed with rheumatic disease, when to see a rheumatologist, and what patients have to say about their experiences of living with rheumatic disease.
Arthritis Foundation
The Arthritis Foundation provides self-care tools and resources covering treatment options, pain management, diet and exercise, and common comorbidities associated with many different arthritic conditions.
EULAR ‘Don’t Delay, Connect Today’ Campaign
This European League Against Rheumatism (EULAR) Campaign aims to raise awareness of the importance of early diagnosis in preventing further damage to those living with rheumatic and musculoskeletal diseases, and to encourage timely access to evidence-based treatment.
European League Against Rheumatism
EULAR is an organization that represents people with arthritis/rheumatism, health professionals, and scientific societies of rheumatology of all the European nations.
Health Topics: Rheumatoid Arthritis
A resource from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for people who have rheumatoid arthritis, as well as for their family members, friends, and others who want to find out more about this disease.
Rheumatoid Arthritis Support Network
The Rheumatoid Arthritis Support Network provides up-to-date information for patients with rheumatoid arthritis, including links to patient support groups, blogs written by patients with rheumatoid arthritis, resources to help pay for medications, and smart device apps to help track symptoms over time.
IBD Patient Resources
Inflammatory Bowel Disease (IBD): What Is It?
Crohn’s and Colitis Foundation
Types of Medications for Crohn’s Disease and Ulcerative Colitis
Treatment Decisions
Advocacy Tools and Resources
Crohn’s Disease and Ulcerative Colitis: Emotional Factors Q & A
The National Institute of Diabetes and Digestive and Kidney Diseases Health Information Center
Crohn’s Disease
Ulcerative Colitis
RA Suggested Readings
Safety and maintenance of response for tofacitinib monotherapy and combination therapy in rheumatoid arthritis: an analysis of pooled data from open-label long-term extension studies.
Fleischmann R, et al. RMD Open. 2017;3(2):e000491.
Upadacitinib (ABT-494) in patients with active rheumatoid arthritis and inadequate response or intolerance to biological DMARDs: a phase 3 randomized, placebo-controlled, double-blind study of a selective JAK-1 inhibitor.
Genovese MC, et al. Arthritis Rheumatol. 2017;69(suppl 10). Abstract 10L.
Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1).
Westhovens R, et al. Ann Rheum Dis. 2017;76(6):998-1008.
Filgotinib (GLPG0634/GS-6034), an oral selective JAK1 inhibitor, is effective as monotherapy in patients with active rheumatoid arthritis: results from a randomised, dose-finding study (DARWIN 2).
Kavanaugh A, et al. Ann Rheum Dis. 2017;76(6):1009-1019.
Response to baricitinib based on prior biologic use in patients with refractory rheumatoid arthritis.
Genovese MC, et al. Rheumatology. 2018;57(5):900-908.
Thromboembolism with Janus kinase (JAK) inhibitors for rheumatoid arthritis: how real is the risk?
Scott IC, et al. Drug Saf. 2018;41(7):645-653.
IBD Suggested Readings
Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial.
Colombel JF, et al. Lancet. 2018;390(10114):2779-2789.
Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease.
Coskun M, et al. Pharmacol Res. 2013;76:1-8.
Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies.
Kim DH, et al. Immune Netw. 2017;11(1):25-40.
The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease.
De Vries LCS, et al. J Crohns Colitis. 2017;11(7):885-893.
JAK inhibition in inflammatory bowel disease.
Olivera P, et al. Expert Rev Clin Immunol. 2017;13:693-703.
Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis.
Sandborn WJ, et al. N Engl J Med. 2017;377(5):496-497.
Clinical remission in patients with moderate-to-severe Crohn’s disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial.
Vermeire S, et al. Lancet. 2017;389(10066):266-275.

JAK-STAT Signaling and Disease Pathogenesis in RA and IBD
Module 1
Faculty: | Allan Gibofsky, MD, JD, MACR, FACP, FCLM; Bruce E. Sands, MD, MS |
Release: | 10/29/2018 |
Expiration: | 10/29/2019 |

JAK Inhibition in Inflammatory Bowel Disease
Module 2
Faculty: | Allan Gibofsky, MD, JD, MACR, FACP, FCLM; Bruce E. Sands, MD, MS |
Release: | 10/29/2018 |
Expiration: | 10/29/2019 |

JAK Inhibition in Rheumatoid Arthritis
Module 3
Faculty: | Allan Gibofsky, MD, JD, MACR, FACP, FCLM; Joel Kremer, MD, FACP |
Release: | 10/29/2018 |
Expiration: | 10/29/2019 |